体形态和疾病表型的关系,在患有神经性厌食症的个体中
Jamie D Feusner1,2,3,4, Alicja Nowacka5, Ronald Ly6
1Centre for Addiction and Mental Health, 250 College St., Toronto, ON, M5T 1R8, Canada. jamie.feusner@utoronto.ca.
Scientific reports
|May 15, 2024
概括
患有神经性厌食症 (AN) 的个体表现出较厚的体区域,与身体形象问题和强迫症症状相关,无论体重如何. 这突显了AN表型中的神经生物学联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 神经性厌食症 (AN) 是一种严重的精神疾病,已知皮质异常.
- 白质变化,包括在体,是建议的,但没有完全探索.
- 体厚度在AN中没有特别研究过.
研究的目的:
- 为了研究与健康对照人群相比,神经性厌食症患者的体厚度.
- 检查体厚度与临床因素 (如BMI,疾病持续时间和饮食障碍症状) 之间的关系.
主要方法:
- 分析了48名患有AN的青少年和成人以及50名健康女性对照者的MRI数据.
- 在不同组之间比较体厚度.
- 与BMI,疾病持续时间和饮食障碍症状严重程度相关联的骨厚度.
主要成果:
- 在整体体厚度方面没有发现任何显著的群体差异.
- 在AN组中,更大的身体形状问题与特定状区域的厚度增加相关 (骨架,骨架,骨架体,地峡,).
- 饮食障碍的强迫症和强迫症与前半身,正面体和脏的厚度增加相关,独立于BMI.
结论:
- 在神经性厌食症中,体厚度没有全球变化.
- 特定的骨区域显示与身体形象问题和强迫症症状相关的厚度增加.
- 研究结果表明,特定的饮食障碍表型与白质结构之间存在神经生物学联系.
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