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Updated: Jun 26, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

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确定Gα12-vs-Gα13-合决定因素,并开发一个Gα12/13-合设计者GPCR

Manae Tatsumi1, Christian Cruz2, Nozomi Kamakura1

  • 1Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.

Scientific reports
|May 15, 2024
PubMed
概括

研究人员确定了控制G蛋白合受体 (GPCR) 选择性对Gα12与Gα13的关键受体残留物. 这一发现使得开发出新型Gα12/13-设计者受体,仅由设计者药物 (DREADDs) 激活,用于向信号.

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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators07:41

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Published on: February 20, 2018

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