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Updated: May 6, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
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一种新型的多宏类抗生素,马奇达素,是由Streptomyces sp.产生的. K22-001717 这是一个很好的例子

Yuta Awano1, Ryoya Ishii2, Yume Takahashi1

  • 1Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

The Journal of antibiotics
|May 15, 2024
PubMed
概括

一种新型的多聚烯宏化物,马奇达胺,从Streptomyces中分离出来. 这种化合物表现出强烈的抗莱什曼尼活性,超过了目前的药物帕罗摩辛.

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Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
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