暴露于热量引起的风险是早产的风险,由母亲的高血压介导
Liyun Wang1,2, Jiangli Di3, Qiong Wang1
1School of Public Health, Sun Yat-sen University, Guangzhou, China.
Nature medicine
|May 15, 2024
概括
在怀孕早期暴露于高温会增加早产风险,因为它会增加母亲的高血压. 这项研究强调了热量.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 孕产妇暴露于热量是对不良妊娠结果的日益关注的问题.
- 以前的研究表明,热量,母亲的血压和早产 (PTB) 之间存在潜在的联系.
- 了解高血压在与热相关的PTB中扮演的调解角色对于公共卫生干预至关重要.
研究的目的:
- 调查怀孕早期暴露于热量和早产风险之间的关联.
- 检查暴露于热量和孕产妇高血压之间的关系.
- 量化孕产妇高血压在多大程度上介导热暴露对PTB的影响.
主要方法:
- 这是一项针对中国 (2015-2018) 197,080名单独生婴儿活产的大型队列研究.
- 用局部温度百分位数 (>85,90,95) 定义的热暴露的分析,从受孕到怀孕20周.
- 用调解分析来评估母亲高血压的作用.
主要成果:
- 怀孕早期暴露于热量与PTB增加15-21%和医学上指示的PTB增加20-22%有关.
- 暴露于热量与增加母亲高血压和高血压的风险有关.
- 孕产妇高血压对PTB的高热暴露 (>第90百分位) 的影响占15.7%,对医学上适用的PTB的影响占33.9%.
结论:
- 在怀孕早期暴露于高环境温度会显著增加早产的风险.
- 暴露于热量有助于早产,部分原因是增加了母亲高血压的发生率.
- 这些发现强调了在怀孕期间减轻暴露于热量的重要性,以减少PTB的发生率.
相关概念视频
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Hormonal Regulation
33.1K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.1K
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Hypertension and Regulation of Blood Pressure
2.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
Homeostatic Imbalances in Body Temperature
122
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
122


