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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
侵袭性医疗干预后的FAPI PET吸收模式:一个单一中心的回顾性分析
Peter George Maliha1,2,3, Masatoshi Hotta4,5, Andrea Farolfi4,6
1Ahmanson Translational Theranostics Division, Department of Molecular & Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA. peter.maliha@mail.mcgill.ca.
干预后纤维细胞激活蛋白成像 (FAPI-PET) 的吸收取决于时间,通常在没有外体放置 (FBP) 的8个月后不存在. 当FBP存在时,FAPI的吸收可以持续数年.
科学领域:
- 核医学是一种核医学.
- 放射化学 放射化学是指辐射化学.
- 在瘤学瘤学.
背景情况:
- 纤维细胞激活蛋白 (FAP) 是由癌症相关纤维细胞 (CAF) 和炎症/纤维化中的激活纤维细胞表达的.
- FAPI-PET 标记剂能够对表达FAP的细胞进行成像,包括那些参与干预后过程的细胞.
- 了解医疗干预后的FAPI吸收模式对于准确的解释至关重要.
研究的目的:
- 为了评估医疗或侵入性非系统干预后[68Ga]Ga-FAPI-46吸收的模式.
- 确定干预地点FAPI吸收的时间进程和影响因素.
主要方法:
- 79名接受[68Ga]Ga-FAPI-46 PET/CT的患者的回顾性分析.
- 审查之前的医疗/侵入性干预,包括外体放置 (FBP).
- 评估FAPI吸收强度 (视觉和定量SUVmax) 和与干预后时间的相关性.
主要成果:
- 分析了163项干预措施,其中26%涉及FBP.
- 在15%的干预中观察到[68Ga]Ga-FAPI-46的吸收,SUVmax的中位数为3.2.
- 在没有FBP的情况下 (中位数9.5个月),与FBP (中位数60.1个月) 相比,FAPI的吸收时间在干预后明显较短.
- 在没有FBP的干预后超过8.2个月后,没有检测到FAPI吸收.
- 与干预后的[68Ga]Ga-PSMA-11相比,[68Ga]Ga-FAPI-46的吸收频率和强度更高.
结论:
- [68Ga]没有FBP的干预后Ga-FAPI-46的吸收取决于时间,通常不超过8个月.
- 多年来持续的FAPI吸收与FBP的存在有关.
- 这些发现有助于区分与干预相关的FAPI吸收与其他病理过程.
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