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中断诱导的治疗折射性被重新评估
Ralph Kupka1,2,3, Eline Regeer4, Annet van Bergen5
1Dept. of Psychiatry, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam Public Health Research Institute, Oldenaller 1, Amsterdam, 1081 HJ, Netherlands. r.kupka@amsterdamumc.nl.
International journal of bipolar disorders
|May 15, 2024
概括
暂停治疗可能会导致一些双相情感障碍患者的治疗折射性. 然而,大多数患者对的再治疗有反应,继续治疗可能会恢复长期的疗效.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 是长期双相情感障碍管理的基石.
- 人们担心在停止和重新开始治疗后,的不响应.
- 中断诱导的治疗折射性 (LDITR) 是一个公认的现象.
研究的目的:
- 审查关于断诱导治疗折射率 (LDITR) 的文献.
- 评估LDITR的流行率和相关因素.
- 为了解决双相情感障碍中治疗的管理提供见解.
主要方法:
- 对案例报告和队列研究的系统文献审查.
- 纳入全国范围的注册研究以获取额外的数据.
- 对队列研究的元分析以确定非响应率.
主要成果:
- 分析了11份病例报告和6项涉及403名患者的队列研究.
- 聚合的队列研究显示,再治疗的不响应率从3.6%到27.7%不等 (平均17.3%).
- 与不响应相关的因素包括更长的治疗持续时间,更长的双相情感障碍持续时间,更快的逐渐减少,以及更长的停药期.
结论:
- 一个小组的患者可能会经历中断诱导的治疗折射性.
- 大多数患者在重新开始使用时恢复反应能力.
- 在最初的复发之后维持治疗可能对长期预防有效性至关重要.
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