纵向分析吸烟与抑郁症状风险之间的关联
Sung Keun Park1, Chang-Mo Oh2, Eugene Kim3
1Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
BMC psychiatry
|May 15, 2024
概括
吸烟增加了抑郁症状的风险,观察到与剂量相关的关系. 即使是前吸烟者也比从未吸烟的人有更高的风险,这凸显了吸烟对心理健康的重大影响.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 精神病学是一个精神病学.
背景情况:
- 在患有抑郁症状的人群中,吸烟率很高.
- 吸烟和抑郁症之间的确切关系仍在争论中.
研究的目的:
- 调查吸烟状态,吸烟量和尼古丁暴露与抑郁症状发展之间的关联.
- 为了澄清吸烟和抑郁风险之间的剂量反应关系.
主要方法:
- 这是一项针对57,441名韩国男性的队列研究,数据收集于2011-2012年间,后续调查至2019年.
- 参与者根据吸烟状况 (从未吸烟,以前吸烟,现在吸烟),吸烟量 (每天一包,每年一包) 和尿液中丁氨酸水平进行分类.
- 考克斯的比例危险模型分析了与吸烟变量相关的抑郁症状风险 (CES-D分数≥16).
主要成果:
- 抑郁症状的风险随着吸烟情况的增加而增加:前吸烟者 (HR=1.08) 和目前吸烟者 (HR=1.24) 的风险比从未吸烟者更高.
- 发现了一种剂量依赖的关系,每日吸烟量和包装年数较高,与抑郁症风险增加有关.
- 尿中高丁氨酸水平也与患抑郁症状的风险增加相对相关.
结论:
- 吸烟暴露与抑郁症状的风险增加显著相关.
- 在吸烟量和抑郁症风险之间存在明显的剂量依赖关系.
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