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来自微生物群的3-烯酸通过Foxo3/NAD⁺信号通路促进肌管缩

Penglin Li¹, Xiaohua Feng¹, Zewei Ma¹

¹State Key Laboratory of Swine and Poultry Breeding Industry, Tianhe District, 483 Wushan Road, Guangzhou, 510642, Guangdong, China.

Cell & bioscience

|May 15, 2024

概括

3-烯酸 (3-PPA) 是肠道微生物的代谢物,通过抑制蛋白质分解和促进乙化来增强骨肌肉的生长. 这一发现揭示了肠肌轴及其在肌肉发育中的作用.

科学领域:

微生物学微生物学
代谢学代谢学代谢学
肌肉生理学肌肉生理学

背景情况:

肠-肌肉轴突出了肠道微生物群代谢物在骨肌肉调节中的作用.
3-phenylpropionic acid (3-PPA) 是一个肠道微生物代谢物,在循环中丰富,其骨肌肉功能在很大程度上尚未被探索.

研究的目的:

为了研究3-烯酸 (3-PPA) 对骨肌肉生长和发育的影响.
阐明3-PPA在肌肉组织中的作用的基础分子机制.

主要方法:

在体内和体外使用C2C12神经管和胚胎初级骨肌细胞的研究.
分析蛋白质降解,蛋白质乙化,NAD+合成和基因表达 (SIRT1/3).
对3-PPA与Foxo3.3的潜在直接结合的研究.

主要成果:

3-PPA在增加肌肉质量和促进肌管缩方面表现出有益作用.
3-PPA抑制了蛋白质降解,并在骨肌细胞中增强了蛋白质乙化.
从机制上讲,3-PPA降低了NAD+合成,抑制了三碳酸循环和SIRT1/3表达,导致蛋白质和Foxo3乙化增加,可能通过直接的Foxo3抑制.

结论:

这项研究首次揭示了3-PPA对骨肌肉生长和发育的影响.
确定了3-PPA,Foxo3和NAD+之间的新型相互作用,机械地促进肌管缩.
这些发现增强了对肠道微生物群代谢物如何通过肠-肌肉轴调节骨肌肉生理学的理解.

关键词:

3 - 烯基烯酸是什么?乙化乙化是一种肠道微生物群的代谢物.肌肉过度缩小肌肉过度缩小它们是NAD+NAD+NAD.

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