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揭示MSC中的异质性:探索基于标记器的策略来定义MSC亚群

Si Chen¹, Bowei Liang¹, Jianyong Xu^2,3

¹Shenzhen University Medical School, Shenzhen University, Shenzhen, 518000, People's Republic of China.

Journal of translational medicine

|May 15, 2024

概括

介质细胞干/干细胞 (MSCs) 是多样化的,影响治疗的一致性. 本综述探讨了MSC标记物用于净化细胞亚型,以获得可靠的治疗疗效和未来的研究.

科学领域:

干细胞生物学干细胞生物学
细胞异质性细胞异质性
再生医学是一种再生医学.

背景情况:

介质细胞干/干细胞 (MSCs) 是适应性强且有望用于疾病治疗.
MSC异质性导致治疗结果变化,阻碍了临床使用.
基于标记物的隔离是一种净化MSC亚群的策略,以保持一致的疗效.

研究的目的:

审查报告的MSC标志物.
探索解决MSC异质性的策略.
确定未来的MSC净化研究方向.

主要方法:

对候选标记器策略的文献综述.
对MSC标记物发现的高通量方法的文献综述.

主要成果:

多国企业表现出显著的异质性.
通过不同的策略,已经确定了各种标记物.
通过标记物进行净化可以提高治疗的一致性.

结论:

解决MSC异质性对于临床翻译至关重要.
基于标记物的净化为一致的MSC疗法提供了一条途径.
对MSC标记物的进一步研究将促进再生医学的发展.

关键词:

细胞标记物细胞标记物身份身份的身份身份的身份多国中心的MSCs.介酶干细胞/介酶干细胞.小部分人口是什么?

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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...