在多发性硬化症期间,CD99对T细胞共刺激的性别和物种特异性贡献
Ingo Winschel1, Anne Willing1, Jan Broder Engler1
1Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Biology of sex differences
|May 15, 2024
概括
跨膜蛋白CD99在男性中表达更高,从而影响人类的T细胞共刺激. 这种特定于性别的规定可能会导致多发性硬化症 (MS) 的易感性.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学是一种遗传学.
- 神经免疫学 神经免疫学
背景情况:
- 像多发性硬化症 (MS) 这样的自身免疫性疾病表现出强烈的性别偏见,主要影响女性.
- 导致自身免疫性疾病发病率性别差异的潜在遗传因素尚不完全理解.
- 超膜蛋白CD99被确定为两性之间显著差异地表达的基因,在男性中表达更高.
研究的目的:
- 研究CD99的性别特异性调节及其在免疫反应中的作用.
- 探索CD99在T细胞调节中的功能影响及其对MS病变发生的潜在贡献.
主要方法:
- 来自基因型-组织表达 (GTEx) 项目的人类脏的基因表达分析.
- 在人类免疫细胞子集中的蛋白质水平验证.
- 在初级人类T细胞和Jurkat T细胞中评估激素调节和T细胞协同刺激测定.
- 使用野生类型和Cd99缺乏的小鼠进行体内研究.
主要成果:
- 与女性相比,CD99基因和蛋白质的表达在男性脏,T细胞和pDC中更高.
- 雄激素不是CD99性别差异的主要原因.
- 与血液相比,大脑脊髓液T细胞中CD99的表达率较高.
- 男性多发性硬化症患者在CSF中的CD4+T细胞上显示较低的CD99水平.
- CD99增强了人类T细胞的激活,并抑制了增殖;CD99缺乏会损害Jurkat细胞中的T细胞功能.
结论:
- CD99在健康个体和多发性硬化症患者中表现出性别特异性调节.
- CD99在人类T细胞共刺激中起作用,但在小鼠中没有作用.
- 不同的CD99表达可能有助于MS的性别特异性发病率和易感性.
关键词:
大脑脊髓液中的脑脊液.实验性的自身免疫性脑膜炎.神经炎症是一种神经炎症.伪自律的地区 伪自律的地区两性二形态主义是一种性别二形态主义.在T细胞共刺激过程中,测试激素 测试激素是什么变性男人 变性男人在X和Y染色体上,染色体是X和Y的.一个X染色体不活化.更多相关视频
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