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使用双能X射线吸收仪在埃及儿科状细胞疾病队列中的身体组成分析
Ahmed Maher Kaddah1, Rania S M Ibrahim2, Seham Gamal1
1Pediatric Hematology and BMT Unit, Department of Pediatrics, Kasr Al-Aini Hospital, Cairo University, Cairo, Egypt.
Pediatric blood & cancer
|May 15, 2024
概括
与健康同龄人相比,患有状细胞疾病 (SCD) 的儿童表现出身体组成的改变,体重和身高较低,但总体质较高. 早期干预对于治疗儿科SCD患者生长衰竭至关重要.
科学领域:
- 儿科血液学 儿科血液学
- 身体组成分析 身体成分分析
- 状细胞疾病研究研究
背景情况:
- 发育不良是儿科状细胞病 (SCD) 的常见并发症.
- 在SCD患者中,可能会发生改变组织区的生长和发展.
研究的目的:
- 为了分析埃及儿科SCD患者的身体组成.
- 使用双能X射线吸收计 (DEXA) 进行全面的,非侵入性的评估.
主要方法:
- 招募了40名患有SCD的儿童 (≤18岁) 和40名年龄/性别匹配的健康对照.
- 从患者记录中收集人口统计,临床和实验室数据.
- 使用MedixDR-全身DEXA系统评估身体组成.
主要成果:
- SCD患者的体重和身高Z分数显著降低 (p < .001).
- 在SCD患者中,总体肌肉质量显著增加 (p = .006).
- 总体脂肪百分比较低,但没有统计学意义 (p = .09). 骨矿物质密度,基础代谢率和脂肪组织分布是可比的.
结论:
- 儿科SCD中的生长需要多学科的方法,包括营养支持和贫血纠正.
- DEXA显示了SCD患者和对照人群之间的可比性体质组成,除了全身瘦.
- 需要进一步的多中心研究,采用更大的样本大小,以验证DEXA在儿科SCD中的实用性.
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