相关实验视频

Updated: Jun 26, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

用PULCON磁共振光谱仪对药物输送系统进行一步精确的表征

C Pesce^1,2, L Goldoni³, V Papa¹

¹Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, 16163 Genoa, Italy.

Molecular pharmaceutics

|May 15, 2024

概括

使用NMR光谱学的新PULCON技术精确量化了药物输送系统中的聚合物度. 这种方法简化了纳米粒子,微粒子和植入物的表征,改善了药物加载和释放控制.

科学领域:

材料科学材料科学材料科学
分析化学分析化学
制药科学制药科学

背景情况:

聚合物对于药物输送系统至关重要,因为它们具有生物降解性和可调节性.
精确的聚合物量化对于控制药物加载和释放至关重要,但仍然是一个重大挑战.
目前用于药物输送系统中聚合物量化的方法可能是复杂和耗时的.

研究的目的:

引入和验证一个新的协议,PULCON,用于药物输送系统中精确的聚合物度量化.
展示PULCON协议在各种交付平台上的应用,包括纳米粒子,微粒子和植入物.
为了使常规的NMR光谱分析能够准确地描述基于聚合物的药物输送系统.

主要方法:

开发一种基于PULCON技术进行聚合物量化的新方案.
使用标准NMR光谱学应用PULCON协议.
药物输送系统的特征,包括由聚乳糖合糖酸 (PLGA),聚乙烯醇 (PVA) 和聚乙烯糖醇 (PEG) 组成的药物输送系统.

主要成果:

普尔康 (PULCON) 协议准确地量化了纳米粒子,微粒子和可植入设备中的聚合物度.
该方法可以在没有内部校准程序的情况下精确确定聚合物和药物含量.
成功应用于使用PLGA,PVA和PEG聚合物的系统.

结论:

普尔康技术提供了一种简单而准确的方法,用于量化各种药物输送系统中的聚合物.
这种基于NMR的方法有助于开发和描述先进的药物输送技术.
该协议在标准NMR光谱仪上易于实施,促进了在制药研究和开发中更广泛的采用.

关键词:

药物输送是药物输送的过程.核磁共振是一种核磁共振.一个聚合物聚合物.量化量化的量化量化量化的量化量化量.

更多相关视频

Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo

Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo

Published on: September 26, 2016

An Integrated Raman Spectroscopy and Mass Spectrometry Platform to Study Single-Cell Drug Uptake, Metabolism, and Effects

An Integrated Raman Spectroscopy and Mass Spectrometry Platform to Study Single-Cell Drug Uptake, Metabolism, and Effects

Published on: January 9, 2020

相关概念视频

Double Resonance Techniques: Overview

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.