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检查产前暴露于感染和儿童大脑形态之间的纵向关联

Anna Suleri¹, Carolin Gaiser², Charlotte A M Cecil³

¹Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, the Netherlands; The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands.

Brain, behavior, and immunity

|May 16, 2024

概括

产前母亲感染暴露,特别是在第三个三个月,影响孩子的大脑发育,可能导致生长轨迹的改变. 这项研究表明大脑区域可能"赶上增长",但需要进一步的研究来确认.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
公共卫生公共卫生

背景情况:

怀孕期间母亲感染是众所周知的后代精神病理的风险因素.
神经成像研究表明,产前感染会影响儿童的大脑结构和功能.
临床前数据表明,随着时间的推移,大脑效应的潜在正常化 (追赶增长).

研究的目的:

研究产前母亲感染暴露与儿童长期神经发育轨迹之间的关联.
通过使用重复的MRI测量,检查妊娠三季度内的母亲感染如何影响儿童大脑的发展.

主要方法:

利用了基于人口的R世代队列 (N=2,155) 的数据.
在每个怀孕季度评估自我报告的感染.
分析了纵向大脑形态 (皮层和皮层下) 使用三个MRI扫描 (8,10,14岁) 与线性混合效应模型.

主要成果:

第三个三个月的感染暴露与轨道部分体积减少的速度较慢,面额前带状,和上额前.
在第三个三个月的感染后,观察到中圈体积增长的速度更快.
不同的极体积变化:随着感染的增加而增加,随着感染的减少而减少.

结论:

产前第三季度感染可能会改变儿童时期特定区域的与年龄相关的大脑生长模式.
结果与临床前"赶上增长"假设一致,但可能代表纵向或时间偏差.
对大脑全面发育的长度研究是必要的,以确认这些观察到的大脑变化的性质.

关键词:

孕产妇的免疫激活神经发育神经发育儿科神经影像学儿科神经影像学基于人口的队列群.产前孕妇感染产前孕妇感染

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