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暴露于来自木材燃烧烟雾的细颗粒物2.5,会导致胎盘的血管变化,并减少胎儿的大小

Francisca Villarroel¹, Nikol Ponce², Fernando A Gómez³

¹Laboratory of Animal & Experimental Morphology, Institute of Biology, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile; MSc. Program in Biological Sciences, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.

Reproductive toxicology (Elmsford, N.Y.)

|May 16, 2024

概括

怀孕期间暴露于木烟颗粒物 (PM2.5) 会损害胎儿发育和胎盘健康. 这种空气污染会影响胎儿的大小和胎盘氧气扩散,给孕妇和胎儿带来风险.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
围产儿医学围产儿医学

背景情况:

母胎流向胎盘的血液流向对胎儿发育至关重要.
木烟暴露对胎盘功能和胎儿生长的影响尚不清楚.

研究的目的:

研究木烟中的颗粒物 (PM2.5) 对大鼠胎盘血管形态生理学和胎儿发育的影响.
评估PM2.5暴露与胎盘氧气扩散能力,血管生成因子表达和胎儿结果之间的关系.

主要方法:

在妊娠前和/或妊娠期间,老鼠暴露在含有PM2.5的过或未过的空气中.
收集了胎盘,测量包括氧气扩散能力,基因表达 (qPCR) 和血管性因素的蛋白质表达 (免疫组织化学).
评估了胎儿的参数,如体重和冠状长度.

主要成果:

在妊娠前和/或妊娠阶段暴露于PM2.5导致胎儿体重,冠长度和胎盘氧气扩散能力下降.
暴露组中观察到HIF-1α的表达增加,表明缺氧.
仅在妊娠前阶段暴露会导致Flt-1,Kdr和PIGF的胎盘表达升高,胎盘迷宫中的血管性因子增加.

结论:

在关键的生殖期暴露于木烟中的PM2.5会对胎儿发育和胎盘健康产生负面影响.
观察到的血管生成和血管生成因子的变化表明对缺氧的适应性反应,影响胎儿的氧气供应和生长.
调查结果强调了木烟空气污染对孕妇及其胎儿的重大健康风险,强调了缓解策略的必要性.

关键词:

血管新生的产生.扩散能力扩散能力微细颗粒物质的细颗粒物质的细颗粒物质氧气过低是因为缺氧.对于PM2.5来说,这是一个很好的例子.胎盘胎盘胎盘胎盘污染问题污染问题

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