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Updated: Jun 26, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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PARP1 与WDR5相互作用,增强目标基因识别并促进瘤发生

Yali Qin1, Xiaochuan Dong2, Manman Lu1

  • 1School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Cancer letters
|May 16, 2024
PubMed
概括

多 (ADP-ribose) 聚合酶-1 (PARP1) 与WDR5相互作用,以调节基因表达和染色素. 联合抑制WDR5和PARP1显著阻碍癌细胞增殖,揭示了新的治疗点.

关键词:
染色体结合的染色体结合在MLL复合体中,MLL复合体PARP1 的第一部分.转录 转录 转录 转录这是WDR5的WDR5.

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