组织工程多功能素改性聚烯带网,装有生物活性植物提取物
Sadaf Nosheen1, Hamid Mukhtar2, Sajjad Haider3
1Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan, 54000; Dr. Ikram-Ul-Haq Institute of Industrial Biotechnology (IIB), GC University, Katchery Road, Lahore, Pakistan, 54000.
International journal of biological macromolecules
|May 16, 2024
概括
表面修饰的聚烯 Hernia Mesh 结合了细菌纤维素和基托桑与植物化学物质,证明了增强的抗拉强度和强大的抗炎,抗菌和伤口愈合特性. 这些生物活性网格为减少手术后并发症,排斥和修复中复发提供了有希望的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 纳米技术 纳米技术
背景情况:
- Hernia 修复通常涉及聚烯 (PP) 网格,但外体反应和感染导致并发症和复发.
- 需要改进的生物材料来提高手术结果,减少患者的不适.
- 现有网格的表面修改提供了一种赋予新功能的策略.
研究的目的:
- 开发具有增强生物相容性和治疗性质的新型,表面修饰的PP网.
- 将细菌纤维素 (BC),奇托 (CS) 和植物化学提取物用于抗炎和抗菌作用.
- 评估功能化网格的物理,化学,生物和体内性能.
主要方法:
- 用BC,CS和植物化学提取物进行功能化的PP网格的制造.
- 使用SEM,机械测试,FTIR和XRD进行表征.
- 评估抗菌活性 (大肠杆菌,黄金杆菌),体外生物相容性 (NIH3T3纤维细胞),伤口愈合潜力和组织工程能力.
- 在21天内对大鼠进行体内植入研究.
主要成果:
- 修改后的网格表现出更好的抗拉强度和物理特性.
- 观察到显著的抗炎,抗菌和伤口愈合特性.
- 在体外和体外评估表明良好的生物相容性和组织整合潜力.
- 该CS-BC生物活性PP网格有效地减少了感染,并显示出治愈的前景.
结论:
- 表面修饰的PP网格包含BC,CS和植物化学物质,是修的有希望的生物材料.
- 这些生物活性网格具有抗炎,抗菌和伤口愈合的能力,可能减少手术后的并发症.
- 开发的功能化网格可以显著减少网格排斥和复发率,改善临床结果.
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