作为预防和辅助治疗的化合物益生菌可以通过肠道微生物群调节效应改善DSS诱导的大肠炎
Siyu Zhou1, Hongxia Zhou2, Jia Qian3
1College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao 266000, China.
International journal of biological macromolecules
|May 16, 2024
概括
化合物益生菌 (CP) 通过改善肠道健康,在预防和治疗结肠炎方面表现有前途. 治疗CP,特别是预防性或与梅萨拉结合,减少炎症和增强有益的肠道细菌.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 大肠炎是一种炎症性肠道疾病,缺乏有效的治疗方法.
- 复合益生菌 (CP) 在治疗大肠炎中的作用尚未完全理解.
- 肠道微生物群失生症是大肠炎病变的一个关键因素.
研究的目的:
- 研究复合益生菌 (CP) 对硫酸 (DSS) 诱导的大肠炎的预防和治疗作用.
- 确定CP是否可以调节肠道微生物群的组成和功能以缓解肠道炎症.
主要方法:
- 在DSS诱导的大肠炎期间,小鼠接受了预防性CP (PCP) 或治疗性CP,美沙或组合 (CPM) 的治疗.
- 评估的参数包括体重,结肠长度,疾病活动指数,组织学分数和细胞因子水平 (IL-10,促炎细胞因子).
- 分析了肠道微生物群的组成 (益生菌),α多样性,短链脂肪酸 (SCFA) 和微生物网络的复杂性.
主要成果:
- PCP和CPM治疗显著改善了结肠炎,改善了临床和组织学的结果.
- CP的使用增加了有益细菌 (Ligilactobacillus,Bifidobacterium,Limosilactobacillus),α多样性和SCFA水平.
- 在益生菌,SCFA,IL-10之间发现了积极的相关性,以及与促炎细胞因子的负相关性.
结论:
- 化合物益生菌 (CP) 显示出作为DSS诱导大肠炎的新型预防和辅助疗法的潜力.
- 治疗CP有效地恢复肠道微生物群的稳态,并减少肠道炎症.
- 通过向肠道微生物群,CP可能为管理炎症性肠道疾病提供了一种新的策略.
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