在调解分析中的间接效应不应该测试统计学意义
1Department of Epidemiology and Data Science, University Medical Centres, Amsterdam, The Netherlands.
Journal of clinical epidemiology
|May 16, 2024
概括
调解分析揭示了间接效应标准误差的问题,特别是当暴露-调解器和调解器-结果关系同样强烈时. 临床相关性,而不是统计学意义,应该指导间接影响的评估.
科学领域:
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 调解分析将暴露结果效应分解为直接和间接组件.
- 在调解分析中一个常见的问题是低估了间接效应的标准误差,与直接和总效应相比.
- 这种标准错误问题在流行病学研究中经常被忽视.
研究的目的:
- 突出介导分析中对间接影响的标准误差估计的问题.
- 提供关于统计测试间接影响的指导.
主要方法:
- 为了说明,利用了两个现实世界的数据集.
- 进行了几次模拟,以调查标准错误估计问题.
主要成果:
- 标准错误估计问题在暴露-介导体和介导体-结果关系具有相似强度时最为重要.
- 这个估计问题的规模取决于调解效应的强度.
结论:
- 在调解分析中不建议对间接效应进行统计显著性测试.
- 调解的临床相关性应该是评估的主要考虑因素.
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