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在水凝微球中的口服素纳米颗粒可以缓解基于肠-大脑轴的高海拔睡眠障碍
Yanping Wu1, Ziyan Tang2, Shumin Du2
1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
International journal of pharmaceutics
|May 16, 2024
概括
新的纳米粒子通过调节肠道细菌和肠-大脑轴来改善高海拔的睡眠. 这表明,有可能预防与高度相关的睡眠问题.
科学领域:
- 生物医学工程 生物医学工程
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 高山睡眠障碍是与急性山病相关的常见问题.
- 调节肠-大脑轴提供了一个潜在的治疗策略.
- 奎尔素的可溶性和生物利用性较差,限制了其有效性.
研究的目的:
- 开发素纳米粒子 (QNP) 封装在水凝微球 (QNP@HMs) 中,以改善传递.
- 在小鼠模型中评估QNP@HMs在预防高海拔睡眠障碍方面的有效性.
- 研究肠道微生物群在QNP@HMs治疗效果中的作用.
主要方法:
- 使用抗溶剂方法制备基于zein的素纳米颗粒 (QNPs).
- 通过电旋转,QNP被装入甲基酸盐水凝微球 (QNP@HMs).
- 在小鼠中诱导高海拔睡眠障碍,QNP@HM被口服.
主要成果:
- 在高海拔地区的小鼠中,QNP@HM的使用延长了睡眠时间和改善了生理恢复.
- 治疗减少了炎症标志物 (TNF-α,iNOS) 和增强了有益的肠道细菌 (Lactobacillus,Lachnospira).
- 在用消毒肠道微生物群的抗生素治疗小鼠中,没有治疗效果.
结论:
- QNP@HM证明了预防高海拔睡眠障碍的巨大潜力.
- 肠-大脑轴和肠道微生物群对于QNP@HMs的治疗作用至关重要.
- 这种配方提供了一种有希望的方法来管理与高度相关的睡眠障碍.
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