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Updated: Jun 26, 2025

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在癌症中,HER3 V104突变调节细胞信号,生长和药物敏感性

Rosalin Mishra1, Mary Kate Kilroy1, Wasim Feroz1

  • 1James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.

Molecular carcinogenesis
|May 16, 2024
PubMed
概括

HER3-V104L突变激活癌细胞生长并降低存活率,而HER3-V104M显示扩散减少. 这两种突变都影响了对HER2,PI3K和ERK抑制剂的反应,突出了它们在癌症治疗中的临床相关性.

关键词:
在HER3中,HER3是HER3.细胞生长细胞的生长.药物敏感性 药物敏感性突变是发生在突变中的突变.有针对性的治疗.

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