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Updated: Jun 26, 2025

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优化双特异性T细胞参与者的临床翻译,通过与定量系统药理学模型的上下文统一

Xiaozhi Liao1, Timothy Qi1, Jiawei Zhou1

  • 1Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Clinical pharmacology and therapeutics
|May 16, 2024
PubMed
概括

量化系统药理 (QSP) 模型可以弥合临床前和临床双特异性T细胞参与剂 (bsTCEs) 数据之间的差距. 这种方法有助于预测患者的反应,并优化用于癌症免疫治疗的BSTCE开发.

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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
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Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
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Physiological Pharmacokinetic Models: Assumption with Protein Binding01:13

Physiological Pharmacokinetic Models: Assumption with Protein Binding

Physiological models with protein binding in pharmacokinetics offer a sophisticated approach to understanding drug disposition. These models consider drug-protein interactions, enabling them to effectively predict drug concentrations in different organs and tissues. This precision aids in accurate drug dosing, providing a significant advantage over conventional models. A key process within these models is equilibration, which ensures that drug concentrations achieve a steady state within the...
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