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Updated: Jun 26, 2025

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血小板糖蛋白和循环之间的结合机制通过基于McMD的动态对接来阐明

Gert-Jan Bekker1, Kanji Oshima2, Mitsugu Araki3

  • 1Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Journal of chemical information and modeling
|May 16, 2024
PubMed
概括

循环OS1抑制了血小板糖蛋白Iba (GPIbA) 和威尔布兰德因子 (vWF) 复合体的形成. 分子动力学模拟显示,GPIbαβ开关的构造变化对于OS1结合和抑制至关重要.

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Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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