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Updated: Jun 26, 2025

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

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MHC-Fine:精细调整的AlphaFold用于精确的MHC-复合体预测

Ernest Glukhov1, Dmytro Kalitin2, Darya Stepanenko1

  • 1Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York.

Biophysical journal
|May 16, 2024
PubMed
概括

我们改进了AlphaFold用于预测主要组织相容性复合体 (MHC) - 结构. 我们精细调整的模型为MHC-相互作用提供了更高的准确性,有助于疫苗设计和计算免疫学.

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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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