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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
双功能方催化氧化动力学分辨率:同时获得轴性罗和硫氧化物
Wei Wen1, Chang-Lin Yang2, Zhu-Lian Wu2
1Key Laboratory of Applied Chemistry of Chongqing Municipality, Chongqing Key Laboratory of Soft-Matter Material Manufacturing, School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
一种新方法使用合方胺催化剂进行硫化物的氧化动力分辨. 这样可以获得具有高选择性的多种轴性性硫乙烯和硫氧化物,从而推进非对称的合成.
科学领域:
- 有机化学 有机化学
- 不对称的催化剂.
- 立体选择性合成 立体选择性合成
背景情况:
- 在非对称转换中,轴性性硫酸乙烯和硫氧化物至关重要.
- 有限的方法可用于合成多种性硫乙烯和硫氧化物.
- 这些化合物作为连接物和有机催化剂具有价值.
研究的目的:
- 开发一种高效的方法来合成多种不同的轴性性硫乙烯和硫氧化物.
- 通过使用性催化剂,建立硫化物的氧化动态分辨率.
- 探索这种方法对基于二的硫化物的应用.
主要方法:
- 硫化物的氧化动态分辨率使用烯氧化.
- 采用一种性双功能方化物作为催化剂.
- 通过键相互作用来研究机制.
主要成果:
- 成功合成了各种轴性的硫化物和硫化物.
- 取得了优异的 diastereo- 和 enantioselectivities. 获得了优异的 diastereo- 和 enantioselectivities. 获得了优异的 diastereo- 和 enantioselectivities. 获得了优异的 diastereo- 和 enantioselectivities.
- 已被证明适用于基于二甲的硫化物.
结论:
- 开发的催化系统可以有效地获取有价值的性硫化合物.
- 该方法扩大了乙烯和硫氧化物不对称合成的范围.
- 结合相互作用是催化剂有效性的关键.
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