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中的N-乙-l-氨酸的药理动力学
Albena Roydeva1, Gabriela Beleva2, Daniel Gadzhakov2
1Department of Pharmacology, Animal Physiology, Biochemistry and Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria.
Journal of veterinary pharmacology and therapeutics
|May 16, 2024
概括
N-乙-l-氨酸 (NAC) 在 brojlers 中具有非常有限的生物可用性 (<10%),在静脉注射后迅速排出. 口服导致血度降低和保留时间延长,影响其在家禽中的使用.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 鸟类医学 鸟类医学
- 动物营养 动物营养
背景情况:
- N-乙-l-氨酸 (NAC) 以其抗氧化特性而闻名,有可能减轻 brojler 的压力.
- 对鸟类种类中NAC的药理动力学数据有限,这阻碍了最佳应用.
研究的目的:
- 为了研究肉中N-乙-l-氨酸 (NAC) 的药理动力学 (PK) 特性.
- 为了确定NAC的吸收,分布和消除特征,通过不同的施用途径.
主要方法:
- 肉接受一次性静脉注射 (IV) 治疗. 或口服 (p.o.) 或口服. NAC剂量,或通过料多次口服剂量.
- 血NAC度使用LC-MS/MS量化.
- 用非分组分析和非线性混合效应建模分析了药理动力学参数.
主要成果:
- 在输液后,NAC表现出快速消除. 管理 (t1/2el ≈ 0.93 h) 和有限的分布.
- 口服导致较长的平均停留时间 (MRT ≈1.76小时) 与静脉注射相比. (≈0.87小时) 的时间.
- 生物利用率始终低 (<10%),口服剂量导致延迟和较低的峰值血度.
结论:
- 在肉中,N-乙-l-氨酸 (NAC) 显示口服生物可用性较差,并快速排出.
- 药物动力学特征表明,通过标准口服或料基础的管理,在家禽中达到NAC的治疗度具有挑战性.
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