视网膜小血管病理与多发性硬化症的疾病负担有关
Rebecca Wicklein1, Linus Kreitner2, Anna Wild1
1Department of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
概括
多发性硬化症 (MS) 导致明显的视网膜血管变化. 小血管损失发生在所有多发性硬化症患者中,而中等血管损失与视神经炎史和质细胞损失有关.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 表面视网膜血管变化在多发性硬化症 (MS) 中很常见.
- 光学连贯断层扫描血管造影 (OCTA) 允许可视化这些变化.
研究的目的:
- 在MS患者中调查视网膜血管变化.
- 为了将这些血管变化与多发性硬化病理和视神经炎 (ON) 史相关联.
主要方法:
- 对259名复发性复发性多发性硬化症患者和78名健康对照者的横截面研究.
- 使用基于深度学习的细分算法对OCTA图像进行分析.
主要成果:
- 在所有MS眼睛中观察到表面血管复合体中小尺寸血管 (<10微米) 的损失,独立于ON史,并与疾病负担相关.
- 中等大小的血管 (10-20微米) 的减少是特定于具有ON史的眼睛,与视网膜质细胞缩相关.
结论:
- 多发性硬化症患者表现出明显的视网膜血管缩模式.
- 需要进一步的研究来阐明这些视网膜血管变化的潜在病理在MS.
相关概念视频
Photoreceptors and Visual Pathways
8.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.5K
Diabetic Retinopathy
55
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
55
Multiple Sclerosis l: Introduction
20
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
20


