乳腺癌基因表达特征:发展和临床意义 - - 叙述性综述
Siyan Li1, Xinmiao Yu1, Yingying Xu1
1Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, China.
概括
乳腺癌基因表达签名有助于在早期疾病的治疗决策. 虽然商业测试提供了预后见解,但全面的临床评估对于个性化患者护理至关重要.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 翻译医学是一种翻译医学.
背景情况:
- 基因表达签名正在迅速发展为乳腺癌.
- 它们旨在阐明瘤生物学,并完善临床治疗策略.
研究的目的:
- 审查在临床实践中关于基因表达特征的争议和共识.
- 为未来的研究方向提供观点和建议.
主要方法:
- 对英语PubMed出版物的综述.
- 专注于2002年至2022年乳腺癌基因表达特征.
主要成果:
- 五个商业签名 (Oncotype,MammaPrint,Prosigna/PAM50,EndoPredict,BCI) 提供了预后和预测评估.
- 它们的临床应用具有挑战性;治疗决策需要综合的临床病理因素.
结论:
- 基因表达特征可以指导早期乳腺癌的辅助疗法,可能节省低风险患者的化疗.
- 对于放射治疗,扩展内分泌疗法和新辅助治疗,需要进一步的数据.
- 个性化治疗需要综合评估,而不仅仅是单一因素.
相关概念视频
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Such genes that act...
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