分子亚型预测男性乳腺癌的预后:一个回顾性队列研究
Min Wang1, Deyue Liu1, Zhaoqi Zhang1
1Department of Breast and Thyroid Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
概括
男性乳腺癌中的分子亚型各不相同,影响生存率. 识别这些亚型可以帮助改善这种罕见疾病的临床策略和患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 男性乳腺癌是一种罕见的疾病,与女性乳腺癌相比,它具有独特的特征.
- 由于缺乏大规模研究,分子亚型及其对男性乳腺癌的预后影响仍然不太清楚.
研究的目的:
- 研究男性乳腺癌患者的特征和生存结果.
- 分析分子亚型在男性乳腺癌中的分布和预后意义.
主要方法:
- 来自监测,流行病学和最终结果 (SEER) 数据库 (2010-2014) 的1597例男性乳腺癌病例的回顾性分析.
- 分子亚型由雌激素受体 (ER),孕激素受体 (PR) 和人体表皮生长因子受体2 (HER2) 状态来定义.
- 使用考克斯回归进行了生存分析,包括总生存率和因果特异性生存率 (CSS).
主要成果:
- 在分子亚型中观察到年龄,种族,年级,瘤大小和AJCC阶段的显著差异.
- 五年CSS率有很大的差异:HR+/HER2的89.2%,HR+/HER2+的78.4%,HR-/HER2+的72.6%,三阴性 (TN) 的43.2%.
- 较差的CSS的独立预后因素包括年龄,负ER/PR状态,TN亚型,晚期AJCC阶段,较大的瘤大小,远程转移和黑人种族.
结论:
- 在男性乳腺癌中,分子亚型各异,类似于女性乳腺癌.
- 这些亚型是生存的关键预测因素.
- 了解分子亚型可以增强临床策略开发和改善患者管理.
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