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Updated: Jun 26, 2025

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Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
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调味品组评价 413 (FGE.413): 纳林金宁
EFSA journal. European Food Safety Authority
|May 16, 2024
概括
一种新的调味剂纳灵宁 (Naringenin) 的安全性得到了评估. 研究没有发现基因毒性或药物相互作用风险. 尽管在老鼠中有一些发育影响,但计算的暴露边际表明,纳灵宁可以安全地作为调味剂使用.
科学领域:
- 食品科学 食品科学 食品科学
- 毒理学 毒理学 毒理学
- 化学安全 化学安全
背景情况:
- 纳灵宁 (FL-no: 16.132) 被评价为一种新的风味物质,根据 (EC) 第1331/2008 条例.
- 没有发现适合的结构类型可用于交叉阅读评估.
研究的目的:
- 评估纳灵宁作为调味剂的安全性.
- 调查潜在的基因毒性,药物相互作用和内分泌干扰活性.
主要方法:
- 对制造工艺,成分和稳定性的评估.
- 基因毒性研究和药物相互作用潜力的评估.
- 在动物中扩展一代毒性研究,以确定没有观察到不良影响水平 (NOAEL).
主要成果:
- 纳灵宁没有显示出任何基因毒性问题.
- 在预期的暴露水平下,药物相互作用的风险不大.
- 根据F2代人的发育影响,NOAEL为1320 mg/kg体重/天.
结论:
- 用NOAEL计算成年人 (1590) 和儿童 (630) 的暴露边际 (MoE).
- 在估计的暴露水平下,纳林根因作为芳香剂的使用不会引发安全问题.
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