HR+早期乳腺癌的顺序与并发辅助化学内分泌疗法:系统性审查和贝叶斯网络元分析
概括
这项研究比较了激素受体阳性早期乳腺癌的辅助化学内分泌疗法. 顺序和并发治疗在绝经前和绝经后的患者中表现出同等的疗效.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 辅助化学内分泌疗法是激素受体阳性 (HR +) 早期乳腺癌的标准.
- 最佳的内分泌方案和整合序列 (顺序与并发) 需要进一步的比较.
研究的目的:
- 为了比较不同辅助化学内分泌治疗方案和HR+早期乳腺癌的整合序列的疗效.
- 根据更年期状态对治疗比较进行分层.
主要方法:
- 在PubMed,Embase,Cochrane图书馆,Web of Science,ClinicalTrials.gov和主要会议摘要的系统文献搜索.
- 包括随机临床试验 (RCT),比较辅助治疗中的化疗和/或内分泌疗法.
- 贝叶斯对无病生存 (DFS) 和整体生存 (OS) 的危险比率的分析.
主要成果:
- 分析了33项试验,包括28515名患者和19种治疗方法.
- 在绝经前的患者中,卵巢功能抑制剂 (OFS) + 芳酶抑制剂 (AI) 显示出比OFS + 塔莫西芬更好的疗效.
- 连续和并发化学内分泌疗法在绝经前和绝经后HR+早期乳腺癌中表现出同等的疗效.
结论:
- 同时和顺序的辅助化学内分泌疗法在绝经前和绝经后HR+早期乳腺癌患者中表现出可比的疗效.
- 治疗建议是基于排名的疗效,强调不同患者群体的特定疗法.
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