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Updated: Jun 26, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Published on: June 9, 2017

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对原型G蛋白结合腺素A2A受体部分激活的结构洞察

Tobias Claff1, Andhika B Mahardhika1,2, Victoria J Vaaßen1

  • 1PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53113, Germany.

ACS pharmacology & translational science
|May 16, 2024
PubMed
概括

研究人员确定了部分腺A2A受体 (A2AAR) 激动剂LUF5834的X射线晶体结构,揭示了关键的结合相互作用. 这一发现解释了部分激动性,并且可能适用于其他G蛋白结合受体 (GPCR).

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