在接受血造干细胞移植的儿科β-血病患者中,营养和身体成分的变化:使用生物电阻分析的回顾性研究
Luyang Zhang1, Li Wang2, Jiewen Long1
1Department of Haematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong Province, 518000, People's Republic of China.
Journal of multidisciplinary healthcare
|May 16, 2024
概括
造血干细胞移植 (HSCT) 对儿科β-血病 (β-TM) 患者的营养状况和身体组成有显著影响. 营养不良的儿童需要在HSCT后集中注意力,因为营养状况下降的风险增加.
科学领域:
- 儿科血液学 儿科血液学
- 营养科学 营养科学
- 移植医学 移植医学
背景情况:
- 儿科β-thalassemia (β-TM) 患者经常面临营养方面的挑战.
- 造血干细胞移植 (HSCT) 是β-TM的治疗方法,但可能会影响营养状况.
- 了解HSCT后的身体组成变化对于患者的治疗结果至关重要.
研究的目的:
- 评估儿童β-TM患者在HSCT前后的营养状况和身体成分变化.
- 探索这些变化与HSCT结果之间的关系.
- 使用生物电阻分析 (BIA) 进行全面评估.
主要方法:
- 对40名接受全源性HSCT的儿科β-TM患者进行了回顾性研究.
- 评估营养状况,人体参数 (BMI,体重,身高) 和身体成分,使用BIA前和后HSCT.
- 对临床结果的分析,包括移植与宿主疾病,移植,粘膜炎和腹.
主要成果:
- 在HSCT后观察到体重,BMI,无脂肪质量 (FFM),骨肌肉质量 (SMM) 和体细胞质量 (BCM) 的显著下降.
- 28.21%的患者在HSCT后经历了营养状况的下降,而以前营养不良患者的发病率更高.
- 根据HSCT后的营养状况,没有发现临床结果的显著差异.
结论:
- 接受HSCT的儿科β-TM患者经历了显著的营养和身体组成变化.
- 营养不良儿童需要有针对性的营养支持和HSCT后的监测.
- 生物电阻分析 (BIA) 对于评估这些变化是有价值的,这表明需要扩展后续和更大的研究.
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