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在新辅助全身疗法后进行乳房手术.

Kate R Pawloski1, Andrea V Barrio1

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概括
此摘要是机器生成的。

新辅助性全身疗法 (NST) 有助于缩小可手术的乳腺癌瘤,增加乳腺保护手术 (BCS) 的资格. 这种方法在各种亚型中是安全和有效的,即使没有完全的反应.

关键词:
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科学领域:

  • 在瘤学瘤学.
  • 乳腺癌研究研究 乳腺癌研究
  • 手术瘤学手术瘤学

背景情况:

  • 新辅助全身疗法 (NST) 用于可操作的乳腺癌,以减少瘤大小,促进乳腺保护手术 (BCS).
  • 病理完整反应 (pCR) 率在三阴性和HER2阳性乳腺癌中最高,但对于BCS资格来说并不重要.
  • 新辅助内分泌疗法 (NET) 是新辅助化疗 (NAC) 的替代方案,用于希望保持乳房的HR+/HER2-绝经后患者.

研究的目的:

  • 评估新辅助全身疗法 (NST) 在乳腺保护手术 (BCS) 中降低可操作乳腺癌的疗效和安全性.
  • 为了比较新辅助化疗 (NAC) 与新辅助内分泌疗法 (NET) 后转化为BCS资格的比率.
  • 评估NST后BCS的瘤安全性和局部复发率 (LR).

主要方法:

  • 对研究新辅助化疗 (NAC) 和新辅助内分泌疗法 (NET) 对可手术乳腺癌的结果的前性试验的审查.
  • 分析不同乳腺癌亚型的乳腺病理完整反应 (pCR) 率和转换为乳腺保护手术 (BCS) 的资格.
  • 在NST后接受乳房保护手术 (BCS) 的患者中评估局部复发率 (LR),强调手术边缘的重要性.

主要成果:

  • 新辅助全身疗法 (NST) 有效地降低了原发性乳腺瘤的发展阶段,增加了所有受体亚型的乳腺保护手术 (BCS) 资格率.
  • 在新辅助化疗 (NAC) 和新辅助内分泌疗法 (NET) 两种疗法中,转化为BCS资格率很高,观察到的率相似.
  • 在NAC和NET后确立了BCS的瘤安全性,当达到负的外科手术边际时,局部复发率 (LR) 可接受的低.

结论:

  • 新辅助全身疗法 (NST) 是一种安全有效的策略,可以为可手术的乳腺癌患者提供乳腺保护手术 (BCS).
  • 实现完整的病理反应不是成功降低阶段和避免乳腺切除的先决条件.
  • 目前正在进行的研究正在探索在特定情况下省略手术,但缺失残留疾病的风险目前限制了这种方法.