研究L-Glu-NMDA受体-H2S-NMDA受体通路,该通路调节大鼠核模糊的胃功能
Hongzhao Sun1, Chenyu Li1, Yuan Shi1
1College of Life Science, Qi Lu Normal University, Jinan, China.
Frontiers in pharmacology
|May 16, 2024
概括
硫化 (H2S) 和L-酸盐 (L-Glu) 注射到核模糊 (NA) 中,调节胃功能. 这项研究揭示了NA中L-Glu-NMDA受体-CBS-H2S通路控制胃运动和酸分泌.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 生物化学 生物化学
背景情况:
- 之前的研究探讨了硫化 (H2S) 和L-谷氨酸 (L-Glu) 通过核模两可 (NA) 注射来调节胃功能.
- 该NA被认为是处理内脏感觉的关键中心.
- 在生理过程中,H2S和L-Glu都起着重要的作用.
研究的目的:
- 在调节胃功能的过程中,研究将L-Glu和H2S连接在一起的潜在途径.
- 阐明核在调解这些效应中的模糊作用.
主要方法:
- 将L-酸盐 (L-Glu),硫化 (NaHS) 和受体对抗剂注入大鼠的核模糊 (NA) 中.
- 使用胃气球监测胃压力和平滑肌肉收缩.
- 在食道 perfusion 之后胃 pH 的分析.
主要成果:
- 将L-谷氨酸 (L-Glu) 注射到NA中显著抑制了胃机动性和增加了胃酸分泌 (p < 0.01).
- 将NaHS注射到NA中也显著抑制了胃机动性和增加了胃酸分泌 (p < 0.01).
- 两种L-Glu和NaHS的作用分别被NMDA受体对手D-AP5和CBS抑制剂AOAA取消.
结论:
- 外源的L-Glu和H2S都通过NA中的NMDA受体调节胃运动和酸分泌.
- 在NA中提出了一种涉及L-Glu,NMDA受体,CBS和H2S的新途径,用于胃功能调节.
相关概念视频
01:37Neural Regulation
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
01:25Regulation of the Digestive System
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of these...
The effectors in this regulation system are glands and smooth muscles. Activation of these...