与正常衰老相比,孤立的REM睡眠行为障碍中的静态和动态大脑形态变化与正常衰老相比.
Gilsoon Park1, Hyunjin Jo2,3, Yaqiong Chai1
1USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Frontiers in neuroscience
|May 16, 2024
概括
孤立的快速眼动睡眠行为障碍 (iRBD) 中的大脑缩不是渐进的,但比正常衰老慢. 在iRBD的认知障碍也不是渐进的,这表明了不同的疾病轨迹.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 睡眠医学 睡眠医学
背景情况:
- 快速眼动睡眠行为障碍 (iRBD) 是神经退行性疾病的一个突发症状.
- 在iRBD中,大脑结构变化在进展和与临床症状的关系方面尚不清楚.
研究的目的:
- 评估iRBD中大脑结构变化是否是渐进的.
- 为了将这些变化与正常的衰老进行比较.
- 研究iRBD中结构变化和临床症状之间的关系.
主要方法:
- 对18名iRBD患者和24名健康对照者的长度研究.
- 磁共振成像 (MRI) 用于皮层厚度和皮层下体积分析.
- 临床检查和神经心理测试.
主要成果:
- 与对照组相比,iRBD患者表现出皮层较薄 (额頭,頭,頭) 和尾状缩.
- 在iRBD中,大脑缩比正常衰老慢,而不是渐进.
- 认知功能,包括执行功能,在基线iRBD患者中较低,但没有呈现逐渐下降.
结论:
- 在iRBD中,大脑缩可能不是渐进的,但表现出比正常衰老更慢的衰退速度.
- 观察到的缩模式与早期帕金森病重叠.
- 在iRBD的认知障碍似乎是非渐进的.
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