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癌症患者的恶性上泌尿道阻塞:系统性审查
Max Shah1, Francesca Blest1, James Blackmur2,3
1University of Bristol Bristol UK.
BJUI compass
|May 16, 2024
概括
恶性上部泌尿道阻塞治疗显示生存率不佳,证据质量有限. 一个新的框架旨在标准化对这种疾病的未来研究的报告.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 证据综合 证据综合
背景情况:
- 恶性上部泌尿道阻塞是全球重要的健康问题.
- 目前治疗的临床证据是分散的,缺乏标准化.
研究的目的:
- 系统地审查临床证据,以治疗新的恶性上泌尿道阻塞.
- 评估报告标准,患者结果,并确定未来的研究需求.
主要方法:
- 系统审查遵循系统审查和元分析 (PRISMA) 准则的首选报告项目.
- 在OVID MEDLINE,EMBASE和Cochrane CENTRAL进行了搜索,直到2022年6月.
- 包括前性和后性研究.
主要成果:
- 包括82项涉及8796名患者的研究,主要是回顾性和调查异质恶性瘤.
- 皮革瘤切除和尿管支架是最受研究的;很少有人检查了没有干预或患者的观点.
- 干预后的中位生存时间约为11.7个月,显著缺乏标准化结果报告.
结论:
- 恶性上泌尿道阻塞治疗的证据基础受到低方法质量和不一致的结果报告的限制.
- 总体生存率似乎很差,需要改进研究设计和报告.
- 提出了一个务实的框架,以指导未来的研究,采用统一的方法.
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