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在宫病变中,与高风险的人类乳头瘤病毒相关的基因型模式的流行率

Varun Kothari¹, Shivani Khullar¹, Hemavaishnave Ts²

¹Microbiology, Dr. Sampurnanand Medical College, Jodhpur, IND.

|May 16, 2024

概括

高风险的人类乳头瘤病毒 (HR-HPV) 感染在印度西部的宫病变女性中很常见. HPV16是最常见的基因型,其次是HPV18和HPV52,还确定了特定的基因型组合.

科学领域:

在瘤学瘤学.
病毒学病毒学
流行病学流行病学

背景情况:

宫病变是一个全球公共卫生问题,主要是由高风险的人类乳头瘤病毒 (HR-HPV) 感染引起的.
HPV 是前恶性宫病变和宫癌的主要原因.
全球HPV基因型分布因地理和生物因素而有所不同.

研究的目的:

确定在西印度宫病变的妇女中HR-HPV基因型的流行率.
为了解决这个特定地区HR-HPV基因型分布的有限研究.
为西印度宫病变的流行病学提供见解.

主要方法:

一项涉及西印度18-60岁215名女性的观察性,横截面研究.
使用TRUPCR® HPV-HR与16/18基因型组件进行了HPV基因型鉴定.
统计分析包括SPSS版本28和学生连续变量t测试.

主要成果:

在宫病变的妇女中,HR-HPV的总体患病率为62.32%.
HPV16是最常见的基因型 (68.65%),其次是HPV18 (24.62%) 和HPV52 (6.7%).
在HR-HPV感染和诸如平等,社会经济地位,农村居住和绝经前状态等因素之间发现了显著的关联.

结论:

在印度西部,HPV16是患有宫病变的妇女中占主导地位的高风险基因型.
该研究确定了流行单个基因型和组合,包括HPV18 + 59和HPV52 + 39 + 51.
结果为指导未来的HPV干预和预防策略提供了有价值的流行病学数据.

关键词:

宫病变是指宫病变的发生.高风险的HPV病毒人类乳头瘤病毒的基因型实时 pcr 在实时 pcr 病毒传输媒介病毒传输媒介

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