在全身麻醉中对雷米马佐拉姆和普罗波的血液动力学影响进行比较分析:一项回顾性研究
Shota Tsukimoto1, Atsuhiro Kitaura2, Rina Yamamoto2
1Department of Dental Anesthesiology, Kanagawa Dental University, Yokosuka, JPN.
Cureus
|May 16, 2024
概括
在麻醉诱导过程中,雷米马佐拉姆导致血压下降较少,心率增加相比,在麻醉诱导过程中与普罗波福尔相比. 血液动力学稳定性在使用雷米马佐拉姆时更好.
科学领域:
- 麻醉学 麻醉学
- 心血管生理学心血管生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 低血压是麻醉诱导期间经常出现的并发症.
- 雷米马佐拉姆是一种较新的麻醉剂,据报道,其血液动力学效应最小.
- 将雷米马佐拉姆的血液动力学概况与普罗波进行比较对于临床实践至关重要.
研究的目的:
- 为了调查remimazolam在麻醉诱导期间具有比propofol更弱的血液动力学效应的假设.
- 通过估计连续心率输出 (esCCO) 系统和心率变化 (HRV) 系统,同时评估血液动力学.
主要方法:
- 一个单中心的观察性回顾性研究,涉及70名在全身麻醉下进行牙科手术的患者.
- 患者被分为两个组:雷米马佐拉姆 (n=34) 和普罗波 (n=36).
- 使用esCCO系统和HRV分析了包括平均动脉血压 (MAP),心率 (HR) 和中风体积 (SV) 在内的血液动力学参数.
主要成果:
- 雷米马佐拉姆组的平均动脉血压下降幅度较小,相比普罗波组的平均动脉血压下降幅度更小.
- 雷米马佐拉姆组的心率显著增加,而在普罗波组心率显著下降.
- 在这两组中,中风体积都下降了,但在雷米马佐拉姆治疗中,这种降低不那么明显.
结论:
- 雷米马佐拉姆的平均动脉血压降低率较低,相比于propofol.
- 尽管中风体积下降,但在使用雷米马佐拉姆时,观察到心率的补偿性增加.
- 随着雷米马佐拉姆的使用,观察到的心率增加并没有归因于自主神经系统活动.
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