预防性止痛疗法在简单拔牙后对疼痛感知的有效性:一项前性研究
Roohika Sharma1, Melvin George1, Murugesan Krishnan1
1Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus
|May 16, 2024
概括
与安慰剂相比,Etoricoxib 90 mg的预防性使用显著减少了成年患者的抽取后疼痛. 在拔牙后的前六小时内观察到最大的疼痛减轻.
科学领域:
- 牙科手术 牙科手术
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 预防性镇痛包括在疼痛刺激之前给予疼痛缓解,以防止中心敏感化.
- 埃托里科克西布90毫克作为止痛剂被探索,以弥合局部麻醉磨损和疼痛发作之间的差距.
- 中枢敏感性,神经系统的过度活动,可以通过预防性镇痛来缓解延长时间的疼痛.
研究的目的:
- 为了研究预防性90毫克埃托里科克西布在治疗抽拔后疼痛方面的疗效.
- 为了比较接受90毫克埃托里科克西布治疗的患者在下第三提取前所经历的疼痛与安慰剂.
主要方法:
- 这是一项双盲,前性,观察性研究,涉及100名参与者 (每组50人).
- 使用视觉模拟尺度 (VAS) 测量疼痛后1,6,12和24小时.
- 独立样本t测试用于统计分析.
主要成果:
- 在所有测量时间点上,研究组 (埃托里可西布) 报告的VAS得分明显低于对照组 (安慰剂).
- 第一个小时的VAS平均得分为3.14 (研究) 和6.40 (对照).
- 在抽取后的前六小时内观察到最显著的疼痛减轻 (P=0.012).
结论:
- 与安慰剂相比,90毫克的预防性埃托里科克西布有效地减少了健康成年人的抽取后疼痛.
- 止痛作用在最初的几个小时是最明显的,在24小时内观察到持续的缓解.
- 这项研究强调了预防性镇痛在改善牙科手术后患者的治疗结果方面所带来的好处.
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