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演变的生长激素缺乏症:概念证明

Sri Nikhita Chimatapu¹, Swathi Sethuram², Julie G Samuels³

¹Division of Pediatric Endocrinology, University of California, Los Angeles (UCLA) Mattel Children's Hospital, Los Angeles, CA, United States.

Frontiers in endocrinology

|May 16, 2024

概括

进化生长激素缺乏症 (EGHD) 可以发生在持续增长不良的儿童中,即使在青春期. 重复生长激素刺激测试 (GST) 对于准确的诊断和管理至关重要.

科学领域:

儿科内分泌学儿科内分泌学
增长和发展增长和发展
激素生理学激素生理学

背景情况:

儿童持续增长不良需要准确的诊断和管理.
生长激素缺乏 (GHD) 是儿童矮身的一个关键考虑因素.
重复增长激素刺激测试 (GST) 在演变中的GHD的诊断实用性需要进一步调查.

研究的目的:

调查成长激素缺乏症 (GHD) 在持续生长衰竭的青少年男性的演变.
为了确定第二个生长激素刺激试验 (GST) 在识别演变的GHD的诊断价值.
分析生长激素 (GH) 治疗对这一群体最终成年人身高的影响.

主要方法:

对于身高矮或生长不良的儿科患者的回顾性图表审查.
纳入标准:进行了两次生长激素刺激试验 (GST).
数据分析包括身高,IGF-1水平和GH峰值反应.

主要成果:

53名患者中有42名是男性;平均初始GH峰值为15.48 ng/ml.
高度SDs随着时间的推移而下降,IGF-1水平仍然很低.
重复GST显示了较低的GH峰值 (7.59 ng/dL),其中36%≤7 ng/dl;12名男性在GH治疗中实现了显著的身高增加.

结论:

证据支持通过重复GST识别的进化生长激素缺乏症 (EGHD) 的概念.
持续增长放缓,即使有青春期进展,也需要仔细的纵向随访.
重复GST对于在持续生长不良的儿童中准确诊断GHD至关重要.

关键词:

增长的增长增长的增长增长的增长.生长激素缺乏,生长激素缺乏.增长激素刺激试验的测试.增长激素治疗的治疗方法异常病态的矮个体.

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