青春期早期的青春期的青春期抑制,其次是丸激素轻微增加了跨男性青年的最终身高
Rebecca W Persky1, Danielle Apple2, Nadia Dowshen2
1Division of Endocrinology, Children's National Hospital, Washington, DC 20010, USA.
Journal of the Endocrine Society
|May 16, 2024
概括
在丸激素治疗之前给予的淋巴激素释放激素激素 (GnRHa) 激剂可以增加跨男性青年 (TMY) 的最终成年人身高 (FAH). 早期的GnRHa治疗为寻求最大限度地提高最终身高的TMY提供了适度的身高优势.
科学领域:
- 内分泌学 在内分泌学.
- 儿科内分泌学 儿科内分泌学
- 跨性别者健康 跨性别者健康
背景情况:
- 变性青少年 (TMY) 可能接受治疗,有时先进行性腺激素释放激素激动剂 (GnRHa) 进行青春期阻塞.
- 众所周知,在某些条件下,GnRHa治疗可以增加最终的身高,例如指定的女性中部早发性.
- 对许多接受性别肯定护理的TMY来说,最大限度地提高最终成年人身高 (FAH) 是一个重要的考虑因素.
研究的目的:
- 为了研究GnRHa治疗在前对成年人最终身高 (FAH) 的影响.
- 为了比较用GnRHa治疗的TMY以及随后的丸激素治疗者与仅用丸激素治疗者之间的FAH结果.
主要方法:
- 在五个美国跨性别健康诊所进行了一项回顾性队列研究.
- 参与者包括32名在青春期初到中期接受GnRHa的TMY,在前接受丸激素 (GnRHa + T组).
- 一个比较组由62名TMY组成,他们仅在晚期/青春期后接受了丸激素 (T-only组).
主要成果:
- 与仅T组相比,GnRHa+T组相对于中父母目标高度 (MPTH) 的FAH显著增加 (+2.3厘米与-2.2厘米相比,P <.01).
- 在GnRHa+T组中,FAH大于预测的成年人身高 (PAH) (1.8厘米,P<0.05),FAH相对于初始身高 (IH) 的z-score更高 (0.5对0.16,P<0.05).
- 每增加一个月的GnRHa单疗与FAH增加0.59厘米相关,而在乳腺阶段3开始GnRHa与相比阶段2降低6.5厘米的FAH相关.
结论:
- 在丸激素治疗前进行青春期前的GnRHa治疗,与各种生长预测和仅用丸激素治疗相比,在变性男性青年中增加了最终的成年人身高.
- 考虑使用GnRHa的TMY应该被告知,早期启动可能会导致最终成年人身高轻微增加.
- 这一发现支持了早期GnRHa干预对TMY高度优化的潜在益处.
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