乙性食道炎:诊断和管理中的当前概念
Fahad I Alsohaibani1, Musthafa C Peedikayil1, Mohammed A Alzahrani2
1Department of Medicine, Section of Gastroenterology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
概括
人们越来越多地诊断出一种慢性炎症性疾病 - - 埃索诺菲尔性食道炎. 针对性疗法,如dupilumab,为管理这种食道疾病提供了新的希望.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 生性食道炎 (EoE) 是一种慢性,抗原介导的炎症性疾病.
- 在过去的二十年中,EoE的发病率和患病率显著增加.
- 临床症状多种多样,主要涉及食道问题,如消化不良和胃烧.
研究的目的:
- 审查当前对乙酸性食道炎的理解和治疗.
- 为了突出针对性疗法在EOE治疗中的出现.
主要方法:
- 关于EoE病理生理学和治疗的最新文献的综述.
- 对包括生物制剂在内的新型向疗法的影响分析.
主要成果:
- 传统的治疗方法 (饮食,PPI,皮质类固醇) 显示出不同的疗效和复发率.
- 基于对EoE病理生理学的更深入理解,有针对性的分子疗法正在出现.
- 杜皮卢马布 (Dupilumab) 是一种IL-4/IL-13抑制剂,是FDA首次批准用于EoE的生物药物,标志着一个范式的转变.
结论:
- 随着向治疗的出现,EoE管理正在不断发展.
- 像杜皮卢马布这样的生物药物代表了治疗异性食道炎的重大进步.
- 对向治疗的进一步研究对于改善患者的治疗结果至关重要.
相关概念视频
Barrett Esophagus-II: Clinical Manifestations and Management
141
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
141
Gastroesophageal Reflux Disease II: Clinical Features and Management
72
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
72
Esophageal Strictures-II: Clinical Features and Management
67
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
67
Barrett Esophagus-I: Introduction
86
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
86
Peptic Ulcer Disease IV: Management
89
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
89
Esophageal Perforation-II: Clinical Manifestations and Management
56
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
56


