晚间时间类型通过在精神分裂症患者中缓解抑郁症状的恶化来影响社会功能
Bilge Çinar1, Şakir Gica2, Pinar Çelikkiran3
1Department of Psychiatry, Ardahan State Hospital, Ardahan, Turkiye.
Chronobiology international
|May 16, 2024
概括
精神分裂症患者的晚间时间型恶化了社会功能,特别是当抑郁症存在时. 睡眠质量不佳进一步加剧了这些负面影响,凸显了综合治疗方法的必要性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 时间生物学 时间生物学
背景情况:
- 睡眠和昼夜节律障碍 (SCRD) 在精神分裂症中很普遍.
- 社会功能受损是精神分裂症的一个核心问题.
- 对于SCRD对精神分裂症患者社会功能的具体影响尚不清楚.
研究的目的:
- 为了研究时间型和缓解精神分裂症患者的社会功能之间的联系.
- 检查抑郁症和睡眠质量在这种关系中的调解作用.
主要方法:
- 185名精神分裂症患者根据时间型 (早晨,晚上,中间) 进行分类,使用早晨-晚上问卷 (MEQ).
- 评估包括积极和消极综合症量表 (PANSS),精神分裂症卡尔加里抑郁量表 (CDSS),个人和社会表现量表 (PSPS) 和匹兹堡睡眠质量指数 (PSQI).
- 使用等级线性回归来分析对PSPS得分的影响.
主要成果:
- 晚间时间型患者表现出更高的抑郁症 (CDSS) 和更差的睡眠质量 (PSQI) 评分.
- 晚间时间类型与较低的整体社会功能 (PSPS-Total) 有关.
- 抑郁症得分显著介导了时间型和社会功能之间的关系.
结论:
- 晚间时间型对缓解的精神分裂症患者的社会功能产生负面影响,特别是当伴有抑郁症状时.
- 睡眠质量和抑郁症是影响这一群体社会结果的关键因素.
- 研究结果强调了解决精神分裂症治疗中的时间型和情绪对于改善社会功能的重要性.
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