对949名粘膜尾瘤患者的预后指标进行了批判性重新评估
Paul H Sugarbaker1, David Chang2
1Program in Peritoneal Surface Malignancy, Washington Cancer Institute, Washington, District of Columbia, USA.
Journal of surgical oncology
|May 16, 2024
概括
细胞还原 (CC) 评分的完整性可靠地预测了尾粘膜瘤的存活率. 在所有患者群体中,腹癌指数 (PCI) 并不是显著的预后指标.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠道瘤学 胃肠道瘤学
背景情况:
- 尾粘膜性瘤与腹膜扩散是通过细胞还原性手术 (CRS) 和高热性腹膜内化疗 (HIPEC) 治疗的.
- 患者选择对于从CRS和HIPEC中获得长期益处至关重要.
- 临床和组织病理学指标指导患者选择CRS和HIPEC.
研究的目的:
- 为四个不同的患者组确定可靠的预后指标,这些患者接受了CRS和HIPEC.
- 评估预后指标对这些群体的整体存活率的影响.
主要方法:
- 对患有低度尾粘膜瘤 (LAMN) 和完整CRS.患者的预后指标的分析.
- 评估粘膜尾腺癌 (MACA) 预后指标的评估与完整的CRS.
- 在MACA中预后指标的评估,包括淋巴结转移 (MACA-LN) 和完整的CRS.
- 检查所有组织学亚型中不完全细胞减少的患者的预后指标.
主要成果:
- 细胞还原 (CC) 评分的完整性在所有三种组织学亚型中显著影响了存活率.
- 腹癌指数 (PCI) 对LAMN和MACA-LN有意义,但对MACA或不完整的CRS没有意义.
- 之前的手术得分 (PSS) 预测了LAMN,MACA-LN和不完整的CRS的结果,但不是MACA.
- 症状患者或接受过广泛化疗的患者的生存率降低.
结论:
- 预后指标的实用性在尾粘膜性瘤子组之间有很大差异.
- 细胞减少 (CC) 评分的完整性是一个始终可靠的预后指标.
- 腹癌指数 (PCI) 在本研究中显示出有限的预后价值.
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