来自深海衍生真菌Penicillium sp. 的神经保护性阿扎菲隆. 这是SCSIO4103030的标志
Weihao Chen1,2, Jiahui Jiang3, Xiaoyan Pang1
1CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. wangjunfeng@scsio.ac.cn.
Organic & biomolecular chemistry
|May 16, 2024
概括
来自深海真菌的新型阿扎菲隆具有神经保护作用. 化合物8和9在保护神经元和促进轴突重生方面表现出潜在的潜力,防止与阿尔茨海默病相关的损伤.
科学领域:
- 海洋天然产品化学 海洋天然产品化学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 深海真菌是新型生物活性化合物的来源.
- 阿扎菲隆是真菌代谢物的一类,具有多样化的生物活动.
- 阿尔茨海默病 (AD) 病理包括神经毒性和轴突损伤.
研究的目的:
- 从深海Penicillium物种中分离和描述新的阿扎菲龙.
- 评估这些化合物的抗瘤,抗病毒和神经保护潜力.
- 研究有前途的阿扎菲隆对神经毒性和轴突缩的影响.
主要方法:
- 使用HPLC,NMR,HRESIMS和ECD计算,分离和阐明十种阿扎菲隆的结构,包括五种新化合物 (penineulones A-E).
- 抗瘤和抗病毒 (HSV-1/2) 活性测定.
- 使用初级培养的皮质神经元进行神经保护测定,针对Aβ25-35诱导的神经毒性.
- 评估轴突的再生和缩.
主要成果:
- 五种新的阿扎菲隆,Penineulones A-E,与五种已知的类似物一起被确定.
- 没有观察到显著的抗瘤或抗病毒活性.
- 阿扎菲隆8和9对Aβ25-35诱导的神经毒性产生显著的神经保护作用.
- 阿扎菲龙8和9促进了轴突的再生和减轻了轴突缩.
结论:
- 深海衍生品Penisillium sp. 在深海衍生. 在SCSIO41030生产新型阿扎菲隆.
- 阿扎菲隆8和9作为神经保护剂具有前景.
- 这些化合物可以作为化合物,用于开发治疗阿尔茨海默氏症等神经退行性疾病的疗法.
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