功能性肠道疾病患者的自然史和结果:一项为期9年的基于人口的纵向研究
Binrui Chen1, Lijun Du1, Yawen Zhang1
1Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Clinical and translational gastroenterology
|May 16, 2024
概括
功能性肠道疾病 (FBD) 的患病率在9年内在中国保持稳定,但症状变化很常见. FBD患者的手术率更高,焦虑和抑郁的风险增加.
科学领域:
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 有限的长期数据存在于社区环境中的功能性肠道障碍 (FBD) 自然史.
- FBD与心理因素之间的关联需要进一步研究.
研究的目的:
- 评估功能性肠道疾病 (FBD) 中症状和健康结果的演变.
- 探索中国人口中FBD和心理障碍之间的关联.
主要方法:
- 随机抽样中国杭州居民进行基线调查 (2010) 和后续电话调查 (2018).
- 根据罗马III标准对FBD进行诊断.
- 评估症状变化,健康结果和心理并发症.
主要成果:
- 功能性肠道疾病 (FBD) 的患病率保持稳定,为36.3% (基线) 和36.1% (随访),其中47%出现症状变化.
- 患有FBD的患者显示,与癌症无关的腹部/盆腔手术发生率更高 (9.8%与3.1%相比).
- 在这两项调查中,FBD与焦虑和/或抑郁有显著的关联,并预测了9年内新发的焦虑/抑郁 (AOR=3.2).
结论:
- 功能性肠道疾病 (FBD) 的患病率稳定,但症状转变频繁.
- 腹部/骨盆外科手术的风险增加和新出现的焦虑/抑郁症与FBD有关.
- 纵向研究对于了解FBD对健康结果和心理福祉的影响至关重要.
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