分子亚型的稳定性和可变性:对原发性和转移性三阴性乳腺癌的比较分析
Xiuzhi Zhu1,2, Xiaohan Ying1,2, Yin Liu2
1Key Laboratory of Breast Cancer in Shanghai, Shanghai Institute of Infectious Disease and Biosecurity, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200000, China.
Cancer biology & medicine
|May 16, 2024
概括
三重阴性乳腺癌 (TNBC) 亚型在进展过程中大多是一致的. 介质细胞样 (MES) 亚型显示过渡和大脑转移的倾向,突出显示需要重复病理确认.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 三重阴性乳腺癌 (TNBC) 是一种异质和侵略性的恶性瘤.
- 以前的分类确定了四种主要的TNBC亚型,但纵向数据有限.
研究的目的:
- 在疾病进展过程中调查TNBC亚型的纵向动态.
- 为了比较TNBC亚型中的原发性和转移性病变.
- 评估与TNBC亚型相关的临床特征和生存结果.
主要方法:
- 分析了880名TNBC患者 (465名早期阶段,415名转移) 的现实世界队列.
- 在疾病进展期间,追踪了TNBC分子亚型的纵向变化.
- 进行了对原发性和转移性病变的比较分析.
主要成果:
- 早期TNBC的3年内复发和转移率为10.1%.
- 转移性TNBC的平均整体存活期为27.2个月,表明预后不佳.
- 在77.5%的患者中,分子亚型保持一致;中介质类 (MES) 亚型显示出过渡和大脑转移的倾向.
- 针对转移性MES亚型病变的精确治疗策略在FUTURE试验中改善了无进展生存率.
结论:
- 大多数TNBC分子亚型在整个疾病进展过程中都是一致的.
- 介质细胞样 (MES) 亚型需要重复病理确认,因为它倾向于过渡和与大脑转移相关联.
- 了解亚型的一致性和动态对于管理TNBC至关重要.
- 针对特定亚型的精准医学方法显示出有前途.
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