怀孕早期母亲的类固醇激素水平和孩子的自闭症:一个基于人口的,嵌套的病例对照研究
Kyriaki Kosidou1, Håkan Karlsson2, Stefan Arver3
1Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden.
Biological psychiatry
|May 16, 2024
概括
在怀孕早期,母亲的类固醇激素可能会影响自闭症的风险. 较低的雌激醇和较高的17-基孕 (17-OHP) 与自闭症有关,其影响因智力障碍 (ID) 而有所不同.
科学领域:
- 神经内分泌学神经内分泌学
- 发育神经科学的发展神经科学.
- 生殖生物学 生殖生物学
背景情况:
- 关于产前类固醇激素在自闭症病因学中的作用,存在相互矛盾的证据.
- 产前暴露于类固醇激素是自闭症发展的一个被提议因素.
研究的目的:
- 为了研究在孕期第一季度雌激醇,,17-基孕 (17-OHP) 和皮质醇的母体血清水平与后代自闭症的几率之间的关联.
- 检查这些关联是否根据同时出现的智力障碍 (ID) 的存在或不存在而有所不同.
主要方法:
- 血清激素水平 (雌激素,,17-OHP,皮质醇) 在怀孕第一季度使用液体染色学-并联质谱法进行测量.
- 限制性立方脊柱逻辑回归模型分析了母体激素和子女中自闭症诊断 (有/没有ID) 之间的关联,并调整了共变量.
主要成果:
- 在母性雌激醇,17-OHP,皮质醇和自闭症之间发现了显著的非线性关联,根据ID状态而有所不同.
- 较低的母性雌激素与ID自闭症的几率增加有关 (OR=1.66).
- 较高的母体17-OHP与没有ID的自闭症几率增加有关 (OR=1.49),而较高的皮质醇与ID的自闭症几率较低有关 (OR=0.55).
结论:
- 怀孕早期母亲的类固醇激素水平可能会导致自闭症的发展.
- 产前类固醇暴露和自闭症之间的关系是复杂的,似乎是由智力障碍的存在调节的.
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