开发和验证一个整合婚姻状况的5年性软骨肉瘤总体存活率的nomogram:一个基于人口的研究
Chengxin Xie1,2, Ruiyuan Jiang3,4, Chenglong Wang1
1Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317099, China.
Discover oncology
|May 16, 2024
概括
婚姻状况会影响瘤存活率,寡妇患者面临最糟糕的结果. 一个新的诺米图准确地预测了冠状骨肉瘤 (CHS) 患者的5年生存期.
科学领域:
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
- 生物统计学 生物统计学
背景情况:
- 软骨肉瘤 (CHS) 是一种罕见的骨癌.
- 了解预后因素对于患者管理至关重要.
- 婚姻状况对CHS存活率的影响尚未得到充分证实.
研究的目的:
- 评估婚姻状况对冠状腺癌患者整体存活期 (OS) 的影响.
- 开发和验证用于预测CHS患者5年生存期的诺米克图.
主要方法:
- 使用了监测,流行病学和最终结果 (SEER) 数据库 (2010-2018).
- 卡普兰-梅尔对生存率的分析.
- 预后因素的单变量和多变量分析.
- 使用哈雷尔的C指数,校准图和决策曲线分析 (DCA) 对名图的外部验证.
主要成果:
- 在CHS患者中,婚姻状况显著影响了OS (P<0.001),而寡妇患者的生存率最低.
- 根据婚姻状况在女性中观察到显著的生存差异,但在男性中没有.
- 年龄,性别,婚姻状况,瘤大小,组织学,等级,SEER阶段和手术是独立的预后因素.
- 该名录实现了高度的内部 (C指数=0.818) 和外部 (C指数=0.88) 验证.
结论:
- 婚姻状况是软骨肉瘤中OS的独立预后因素.
- 寡妇患者和男性患者的预后通常较差.
- 开发的诺米图是预测5年后的生存状况和识别高风险冠状腺癌患者的宝贵工具.
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