测试细菌性阴道炎在次生育人口和时间到怀孕:一个前性队列研究
Marjolein van den Tweel1,2, Ellen van den Munckhof3, Moniek van der Zanden2
1Department of Obstetrics and Gynecology, Leiden University Medical Center, 2300RC, Leiden, The Netherlands.
Archives of gynecology and obstetrics
|May 16, 2024
概括
细菌性阴道炎 (BV) 可能对需要生育治疗的不孕个体的怀孕时间表产生负面影响. 然而,BV对一般不育夫妇或那些有不明原因不育症的夫妇的怀孕率没有影响.
科学领域:
- 生殖医学 生殖医学
- 微生物组研究 微生物组研究
- 传染性疾病 传染性疾病
背景情况:
- 低生育率影响了世界各地的许多夫妇,各种因素影响了受孕.
- 细菌性阴道炎 (BV) 是一种常见的阴道疾病,越来越多地研究其在生殖健康方面的潜在作用.
- 了解阴道微生物组改变对生育结果的影响对于开发有针对性的干预措施至关重要.
研究的目的:
- 为了研究细菌性阴道炎 (BV) 与不育夫妇怀孕的时间之间的关联.
- 为了确定VB是否影响到正在进行的怀孕和活产的时间.
- 为了探索这些协会在不同的子群的子育种群,包括那些无法解释的子育和那些适用于生育治疗.
主要方法:
- 在2019年7月至2022年6月期间,对163对不育夫妇进行初步生育评估的前性研究.
- 用pH,qPCR和16S rRNA基因测序分析BV的阴道样本.
- 使用卡普兰-梅尔和考克斯回归模型分析的持续怀孕 (12周) 和活产的时间,经过调整以考虑混因素.
主要成果:
- 27%的参与者在初始评估时检测出BV阳性.
- 在一般的不孕群中,BV状态没有显著影响到正在进行的怀孕或活产的时间.
- 在适用于生育治疗的不育个体中,BV与显著更长的怀孕时间有关 (aHR 0.19).
- 微生物群体状态类型III和IV也与那些适用于生育治疗的孕妇怀孕的时间更长有关.
结论:
- 细菌性阴道炎可能会对需要生育治疗的次生育个体的生育时间产生负面影响.
- 在一般的不孕人口或那些有不明原因的不孕症的人群中,BV和怀孕时间之间没有发现任何关联.
- 需要进行进一步的研究,以探索BV在无法解释的不孕症中的作用以及BV治疗对生育结果的潜在益处.
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